PET imaging of CD105/endoglin expression with a 61/64Cu-labeled Fab antibody fragment
نویسندگان
چکیده
منابع مشابه
PET Imaging of Abdominal Aortic Aneurysm with 64Cu-Labeled Anti-CD105 Antibody Fab Fragment.
UNLABELLED The critical challenge in abdominal aortic aneurysm (AAA) research is the accurate diagnosis and assessment of AAA progression. Angiogenesis is a pathologic hallmark of AAA, and CD105 is highly expressed on newly formed vessels. Our goal was to use (64)Cu-labeled anti-CD105 antibody Fab fragment for noninvasive assessment of angiogenesis in the aortic wall in a murine model of AAA. ...
متن کاملClinical and technical considerations for imaging colorectal cancers with technetium-99m-labeled antiCEA Fab' fragment.
OBJECTIVE Colorectal cancer is the third most common cancer, after lung and breast cancers. Approximately 133,500 Americans develop colorectal cancer annually and approximately 54,900 die of the disease. As many as 600,000 individuals in the US are under care after surgery for colorectal cancer. After reading this article, the nuclear medicine technologist will be able to: (a) describe the role...
متن کاملHighly Specific PET Imaging of Prostate Tumors in Mice with an Iodine-124-Labeled Antibody Fragment That Targets Phosphatidylserine
Phosphatidylserine (PS) is an attractive target for imaging agents that identify tumors and assess their response to therapy. PS is absent from the surface of most cell types, but becomes exposed on tumor cells and tumor vasculature in response to oxidative stresses in the tumor microenvironment and increases in response to therapy. To image exposed PS, we used a fully human PS-targeting antibo...
متن کاملHigh contrast tumor imaging with radio-labeled antibody Fab fragments tailored for optimized pharmacokinetics via PASylation
Although antigen-binding fragments (Fabs) of antibodies constitute established tracers for in vivo radiodiagnostics, their functionality is hampered by a very short circulation half-life. PASylation, the genetic fusion with a long, conformationally disordered amino acid chain comprising Pro, Ala and Ser, provides a convenient way to expand protein size and, consequently, retard renal filtration...
متن کاملConstruction of a human recombinant polyclonal Fab fragment antibody library using peripheral blood lymphocytes of snake bitten victims
Human snake bitten poisoning is a serious threat in many tropical and subtropical countries such as Iran. The best acceptable treatment of envenomated humans is antivenoms; however they have a series of economic and medical problems and need more improvements. In this study a combinatorial human immunoglobulin gene library against some of Iranian snakes venoms was constructed. Total RNA prepare...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: European Journal of Nuclear Medicine and Molecular Imaging
سال: 2013
ISSN: 1619-7070,1619-7089
DOI: 10.1007/s00259-012-2334-2